Laboratory in Tissue
Spectroscopy and Bio-Signatures
|
| Book Chapters |
| Barton J,
Tumlinson A, Utzinger
U. "Combined
endoscopic OCT and laser induced fluorescence
" in Optical Coherence Tomography:
Technology and Applications, edited
by
Wolfgang Drexler and James Fujimoto (Springer),
in press, 2008. (Spectra) |
Richards-Kortum
R, Drezek R, Basen-Engquist
K, Cantor S, Utzinger U,
Brookner C, Follen M. "Chapter
9: Cervical
Dysplasia Diagnosis with Fluorescence
Spectroscopy. Handbook of Biomedical
Fluroescence, edited by Brian Pogue,
PhD, and Mary Ann Mycek, PhD. Marcel
Deckker: New York, NY, 2003. |
| Utzinger
U, Richards-Kortum R, Fundamentals
of spectroscopy: fiber optic probes, Encyclopedia
of spectroscopy and spectrometry,
ed John Lindon, George Tranter, John Holmes,
Academic Press Ltd., 1999. |
|
| Theses
and Dissertations |
Matthew
S Chan, Introduction
to Time Correlated Single Photon Counting
and Proposed Reference Standards for
Fluroescence Lifetime Microscopy,
Protocol: Bead
Prepartion, OSC MS Report,
December 2007.
|
Michalis
Michaelides, Early
Detection of Ovarian Cancer Using
Fluorescence
Spectroscopy and Parallel Factor
Analysis,
Defense Presentation, ECE MS Thesis,
December 2007.
|
Archana
Chandrasekaren, Calibration
and Quality Control of Clinical Spectroscopy
Device, Defense Presentation, ECE MS Thesis, November
2007.
|
Bill
Brands, Optical
Studies of Collagen Crosslinking,
Angiogenesis and Matrix Metalloproteinases, BME
MS Report, October 2007.
|
Ned
Kirkpatrick, Functional
Biological Spectroscopy and Multiphoton
Imaging
Using Endogenous Optical Contrast,
BME PhD Disseration, November 2006.
|
| Blaise
Lovisa, Multispectral
Imaging System for In Situ Tissue spectroscopy
in the UVC, IBT/ETH MS Thesis, January
2006. |
| Jamie
Dibble, Matrix
Metalloproteinase Expression in the
Development of Ovarian Cancer,
Mentor: M Brewer, BME, MS Report, June
2005. |
Ramkumar
Krishnamurty, Multispectral
Imaging System to Detect Cancer in
the Ovaries, ECE MS Thesis, Fall
2004.
|
| Saurabh
Srivastava, Computer-Aided
Identification of Ovarian Cancer in
Confocal Microendoscope
Images,
ECE MS Thesis, Mentor: A Gmitro |
| Michael
Bueeler, Design
Optimization and Quality Control of
a Fluorescence and Reflectance
Spectroscopy System,
IBT/ETH MS Thesis, March 2000. |
| George
Raeber, Design
and Assembly of a Weakly Confocal Scanning
System,
IBT/ETH MS Thesis, September 1998. |
|
| Papers
2007 |
| Kirkpatrick
N, Brewer MA, Utzinger
U. Endgenous
Optical Biomarkers of Ovarian Cancer
Evaluated with Multiphoton Microscopy.
Cancer Epidemiology Biomerakers Prev,
16(10):2048-2057, Ocotber 2007.
Supplemental materials: Normal, Abnormal |
| Kirkpatrick
N, Andreou S, Hoying J, Utzinger
U. Live
imaging of collagen remodeling during
angiogenesis.
American Journal of Physiology: Heart
and Criculation, 292:H3198-H3206, February
2007. Supplemental materials: S1, S2 |
| Hariri LP,
Tumlinson AR, Wade NH, Besselsen DG, Utzinger
U, Gerner EW, Barton JK. Ex
vivo optical coherence tomography
and
laser induced fluorescence spectroscopy
imaging of murine gastrointestinal
tract.
Comparative Medicine, 57(2):175-85, 2007. |
|
| Papers
2006 |
| Sun J,
Fu K, Wang A, Lin AWH, Utzinger
U, and Drezek, R. The
influence of fiber optic probe geometry
on the applicability of inverse models
of tissue reflectance spectroscopy:
computational models and experimental
measurements. Applied
Optics, 45(31):8152-62, 2006. |
| Kirkpatrick
N, Hoying J, Botting S, Weiss J, Utzinger
U. In
vitro model for endogenous optical signatures
of collagen. Journal of
Biomedical Optics, 11:054021, 2006. |
| Brewer M, Kirkpatrick
ND, Wharton JT, Wang J, Hatch K, Auersperg
N, Bast R, Utzinger U,
Gershenson D, Bast R, Zou C. 4-HPR
modulates gene expression in ovarian cancer
cells. International Journal
of Cancer, 119(5):1005-13, 2006. |
McNally
JB, Kirkpatrick ND, Hariri LP, Tumlinson
AR, Besslesn DG, Gerner EW, Utzinger
U, Barton JK. Task
based imaging of colon cancer in a mouse
model (ApcMin/+). Applied
Optics, 45(13):3049-62, 2006. |
Hariri LP,
Tumlinson AR, Wade NH, Besselsen DG,
Utzinger U, Gerner
E, Barton JK. Endoscopic
optical coherence tomography and laser
induced fluorescence spectroscopy in
a murine colon cancer model.
Laser in Surgery and Medicine 38(4):305-13,
2006.
|
|
| Papers
2005 |
Kirkpatrick
ND, Zou C, Brewer MA, Brands WR, Drezek
RA, Utzinger U, Endogenous
fluorescence spectroscopy of cell suspensions
for chemopreventive drug monitoring.
Photochemistry and Photobiology, 81:125-134,
2005. |
|
| Papers
2004 |
Wang A,
Bender J, Pfefer JT, Utzinger
U, Drezek RA, Depth
sensitive reflectance measurements
using
obliquely oriented fiber probes.
Journal of Biomedical Optics, 10:044017,
2005. |
Brewer MA,
Utzinger U, Barton
JK, Hoying JB, Kirkpatrick ND, Brands
WR, Davis JR, Hunt K, Stevens SJ, Gmitro
AF, Imaging
of the Ovary. Technology in Cancer
Research & Treatment, 3(6): 617-627,
December 2004. |
| Tumlinson AR,
Hariri LP, Utzinger U,
Barton JK, Miniature
endoscope for simultaneous optical coherence
tomography and laser-induced fluorescence
measurements. Applied Optics 43(1):113-121,
2004. |
| |
| Papers
2003 |
| Utzinger
U, Bueeler M, Oh, S, Heintzelman
DL, Svistun ES, Abd-El-Barr M, Gillenwater
A, Richards-Kortum R, Optimal
Visual Perception and Detection of
Oral
Cavity Neoplasia, IEEE
Transactions on Biomedical Engineering
50(3): 396-399, 2003. |
| Brookner C,
Utzinger U, Follen M,
Richards-Kortum R, Cox D, Atkinson EN,
Effects
of biographical variables on cervical
fluorescence emission spectra, Journal
of Biomedical Optics 8(3): 479-483, July
2003 |
| Cox D, Chang
SK, Dawood MY, Staerkel G, Utzinger
U, Richards-Kortum R, Follen
M,
Detecting the Signal of the Menstrual
Cycle in Fluorescence Spectroscopy of
the Cervix, Applied Spectroscopy,
57(1):67-72, 2003. |
| Utzinger
U, Richards-Kortum R, Fiberoptic
probes for optical spectroscopy,
review article, Journal
of Biomedical
Optics, 8(1):121-147, 2003. |
|
| Papers 2002 |
| Chang SK,
Dawood Y, Staerkel G, Utzinger
U,
Richards-Kortum R, Follen M, Fluorescence
spectroscopy for Cervical Pre-Cancer
Detection:
Is There Variance Across the Menstrual
Cycle?, Journal of Biomedical
Optics, 7(4):603-608, 2002. |
Chang S, Follen
M, Malpica A, Utzinger U,
Staerkel G, Cox D, Atkinson EN,
MacAulay C, and Richards-Kortum R, Optimal
Excitation Wavelengths for Discrimination
of Cervical Neoplasia, IEEE Transactions
on Biomedical Engineering, 49(10): 1102-110,
2002. |
| MacAulay C,
Richards-Kortum R, Fedyk A, Atkinson EN,
Cox D, Follen M, Utzinger U,
Variation
of fluorescence spectroscopy during the
menstrual cycle, Optics Express, 10(12):493-504,
2002. |
| Myakov A,
Wicky L, Savchenko N, Utzinger
U,
Richards-Kortum R, Sokolov K, Fiber
optic probe for polarized reflectance
spectroscopy in vivo: design and performance,
Journal of Biomedical Optics7:388-97,
2002. |
| Brewer M,
Utzinger U, Li Y, Atkinson
N, Satterfield W, Richards-Kortum R,
Follen
M, Bast RC, Fluorescence
Spectroscopy as a Biomarker in a Cell
Culture and in a Non-Human Rhesus Primate
Model for Ovarian Cancer Chemopreventive
Agents, Journal of Biomedical
Optics, 7(1):20-26, 2002. |
| Brewer M,
Baze W, Hill H, Utzinger U,
Wharton JT, Follen M, Khan-Dawood F,
Satterfield
W,
Non-Human Primate Model for Ovarian Cancer
Chemoprevention, Comparative Medicine
51(5):424-429, 2002. |
|
| Papers
2001 |
| Drezek R,
Sokolov K, Utzinger U,
Boiko I, Malpica A, Follen M, Richards-Kortum
R, Understanding
the contributions of NADH and Collagen
to cervical tissue fluorescence spectra:
modeling, measurements and implications,
Journal of Biomedical Optics, 6:385-96,
2001. |
| Utzinger
U, Heintzelman DL, Mahadevan-Jansen
A, Malpica A, Follen M, Richards-Kortum
R, Near
infrared Raman spectroscopy for in vivo
detection of cervical precancers,
Applied Spectroscopy, 55(8):955-959, 2001. |
| Brewer M,
Utzinger U, Silva E,
Gershenson D, Bast RC, Follen M, Richards-Kortum
R, Fluorescence
spectroscopy for in vivo characterization
of ovarian tissue, in press, Lasers
in Surgery and Medicine, 29:128-135,
2001. |
| Coghlan L,
Utzinger U, Richards-Kortum
R, Brookner C, Zuluaga A, Gimenez-Conti
I, Follen M, Fluorescence
spectroscopy of epithelial tissue throughout
the dysplasia-carcinoma sequence in an
animal model: spectroscopic changes precede
morphologic changes, Lasers in Surgery
and Medicine, 29:1-10,2001. |
| Brewer M,
Utzinger U, Satterfield
W, Hill L, Gershenson D, Bast RC, Wharton
JT, Richards-Kortum R, Follen M, Biomarker
modulation in a non-human rhesus primate
model for ovarian cancer chemoprevention,
Cancer Epidemiology Biomarkers and Prevention,
10:889-893, 2001. |
| Utzinger
U, Brewer M, Silva E, Gershenson
D, Bast RC, Follen M, Richards-Kortum
R, Reflectance
spectroscopy for in vivo characterization
of ovarian tissue, Lasers in Surgery
and Medicine, 28:56-66, 2001. |
|
| Papers 2000 |
| Coghlan L,
Utzinger U, Drezek U,
Heintzelman DL, Zuluaga A, Brookner C,
Richards-Kortum, Gimenez-Conti I, Follen
M, Optimal
fluorescence excitation wavelengths for
detection of squamous intra-epithelial
neoplasia: results from an animal model,
Optics Express 7(12):436-446, 2000. Video |
| Heintzelman
DL, Utzinger U, Fuchs
H, Zuluaga A, Gossage K, Gillenwater A,
Jacob R, Kemp B, Richards-Kortum R; Optimal
excitation wavelengths for in vivo detection
of oral neoplasia using fluorescence spectroscopy,
Photochemistry and Photobiology 72(1):103-113,
2000. |
|
| Papers 1999 |
| Utzinger
U, Trujillo EV, Atkinson EN,
Follen-Mitchell M, Cantor SB, Richards-Kortum
R,
Performance estimation of diagnostic tests
for cervical pre-cancer based on fluorescence
spectroscopy: effects of tissue type,
sample size, population and signal to
noise ratio, IEEE Transactions on
Biomedical Engineering, 46(11):1293-303,
1999. |
| Mitchell MF,
Cantor SB, Brookner C, Utzinger
U, Schottenfeld D, Richards-Kortum
R, Screening
for squamous intraepithelial lesions with
fluorescence spectroscopy. Obstetrics
& Gynecology. 94(5 Pt 2):889-96, 1999. |
| Agrawal A,
Utzinger U, Brookner
C, Pitris C, Mitchell MF, Richards-Kortum
R, Fluorescence
spectroscopy of the cervix: influence
of acetic acid, cervical mucus, and vaginal
medications, Lasers in Surgery &
Medicine 25(3):237-49, 1999. |
| Brookner CK,
Utzinger U, Staerkel
G, Richards-Kortum R, Mitchell MF, Cervical
fluorescence of normal women. Lasers
in Surgery & Medicine. 24(1):29-37,
1999. |
| Zuluaga A,
Utzinger U, Durkin T,
Fuchs H, Gillenwater A, Richards-Kortum
R, Fluorescence
excitation emission matrices of human
tissue: a system for in vivo measurement
and method of data analysis, Applied
Spectroscopy, 53(3):302-311, 1999. |
|
| Papers 1998 |
| Mahadevan-Jansen
A, Follen Mitchell M, Ramanujam N, Utzinger
U, Richards-Kortum R; Development
of a fiber optic probe to measure NIR
Raman spectra of cervical tissue in vivo,
Photochemistry and Photobiology, 68(3):427-31,
1998. |
| Mahadevan-Jansen
A, Follen Mitchell M, Ramanujam N, Malpica
A, Thomsen S, Utzinger U,
Richards-Kortum R; Near-infrared
Raman spectroscopy for detection of cervical
precancers, Photochemistry and Photobiology,
68(1):123-32, 1998. |
| Trujillo EV,
Sandison DR, Utzinger U,
Ramanujam N, Follen-Mitchell M, Richards-Kortum
R,
A method to determine tissue fluorescence
efficiency in vivo and predict signal
to noise ratio for spectrometers,
Applied Spectroscopy, 52 (7): 943-951,
1998. |
| Strebel RT,
Utzinger U, Peltola M,
Schneider J, Niederer PF, Hess OM,
Excimer laser spectroscopy: influence
of tissue ablation on vessel wall fluorescence,
Journal of Laser Applications, 10(1):
34-40, 1998. |
|
Papers 1995 |
| Mayer IV, Lazarov
MP, Utzinger U, Freiburghaus
AU, Hess OM, Sonicated
X-ray contrast agents for quantitative
myocardial contrast echocardiography -
a critical approach, Heart
& Vessels, 10(2): 96-105, 1995. |
| Kaufmann P,
Vassalli G, Utzinger U,
Hess OM, Coronary
vasomotion during dynamic exercise: influence
of intravenous and intracoronary nicardipine,
Journal of the American College of Cardiology,
26(3): 624-31, 1995. |
|
| Papers 1992 |
| Bosshart F,
Utzinger U, Hess OM,
Wyser J, Mueller A, Schneider J, Niederer
P, Anliker M, Krayenbuehl HP, Fluorescence
Spectroscopy for identification of atherosclerotic
tissue, Cardiovascular
Research, 26(6): 620-5, 1992. |
|
| Papers
1990 |
| [1] Dillier
N, Senn C, Schlatter T, Stockli M,
Utzinger U, Wearable
digital speech processor for cochlear
implants using a TMS320C25,
Acta Oto-Laryngologica - Suppl., 469:
120-7, 1990. |
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